期刊
OBESITY SURGERY
卷 25, 期 6, 页码 1031-1038出版社
SPRINGER
DOI: 10.1007/s11695-014-1471-z
关键词
Roux-en-Y gastric bypass; Fatty acids; Vitamin A; Vitamin E
类别
Fatty acid (FA) profile is often altered, in morbidly obese subjects, both before and after bariatric surgery. We measured FA plasma levels before and 6 months after Roux-en-Y gastric bypass (RYGB), in order to evaluate their relationship with different biological and psychological parameters and the impact of RYGB on the FA plasma levels. Thirty eight morbidly obese patients were investigated before RYGB, and 28 of them were reexamined 6 months postoperatively. Anxiety, depression, and quality of life were evaluated by validated questionnaires. Plasma FA (saturated, monounsaturated, polyunsaturated omega-6 and omega-3), vitamins A and E, fasting insulinemia, and high-sensitive C-reactive protein (hs-CRP) were measured. Before surgery, omega-3 polyunsaturated FA and vit A showed significant negative relationship with fasting insulinemia (gamma-linolenic p = 0.03, eicosapentaenoic, vit A p = 0.01) and hs-CRP (eicosapentaenoic p = 0.03, vit A p = 0.02) and a positive link with HDL cholesterol (gamma-linolenic p = 0.03, vit A p = 0.02). Depression score was significantly and negatively linked with palmitoleic (p = 0.03), gamma-linolenic (p = 0.006), dihomo-gamma-linolenic (p = 0.02), and alpha-linolenic (p = 0.03) acids. After surgery, FA and both vit A and E were significantly reduced. Vit A levels were below 2.4 mu mol/l in 63 % of the patients, preoperatively, and in 79 % after surgery. Preoperative levels of linoleic acid were significantly related with the postoperative weight reduction (p = 0.0006). FA are involved in several biological and psychological functions. The RYGB-induced reduction of FA could have deleterious consequences on vitamin absorption, metabolism, and depression. Thus, the surveillance of FA levels is of primary importance both before and after RYGB.
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