期刊
OBESITY SURGERY
卷 18, 期 11, 页码 1424-1429出版社
SPRINGER
DOI: 10.1007/s11695-008-9560-5
关键词
PYY; Ghrelin; Obesity; Bariatric surgery
类别
资金
- Instituto de Salud Carlos III [CP04/00133]
- Ciber Fisiopatolog a Obesidad y Nutricion [CB06/03/0018]
- Ciber Diabetes y Enfermedades Metabolicas [CB07/08/0019]
- Instituto de Salud Carlos III
Background The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery. Methods Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n=38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n=13). Results RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p=0.001). Ghrelin rose significantly after RYGB (p=0.022) but not after BPD. After surgery, PYY correlated positively with weight (r=0.416, p=0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p=0.002) and ghrelin (p=0.018). Conclusions BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin.
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