期刊
OBESITY FACTS
卷 6, 期 4, 页码 393-404出版社
KARGER
DOI: 10.1159/000354574
关键词
Resistin; Metabolic syndrome; Insulin resistance; Childhood obesity; Inflammation
资金
- Ministry of Higher Education and Scientific Research of Tunisia
Objective: The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO). Methods: 114 obese adolescents (60 Ob, age 13.6 +/- 0.9 years, BMI 28.0 +/- 2.2 kg/m(2), and 54 Ob-MS, age 13.8 +/- 1.0 years, BMI 32.5 +/- 4.8 kg/m(2)) and 37 CO (age 13.7 +/- 0.8 years, BMI 22.8 +/- 0.8 kg/m(2)) were studied. Anthropometrics, cardiac variables as well as fasting plasma concentrations of lipids, glucose, insulin, and adipocytokines (resistin, tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), C-reactive protein (CRP)) were measured. HOMA-IR was calculated, and the presence of MS was assessed. Results: Plasma resistin was significantly higher in Ob-MS than in both Ob and CO and was correlated with anthropometric, cardiovascular, pro-inflammatory markers and several components of MS as was HOMA-IR in Ob and Ob-MS. With increasing the number of MS components, plasma resistin, pro-inflammatory markers, and HOMA-IR were also increased. Multiple regression models highlighted significant correlation between resistin and both HOMA-IR (r = 0.40, p < 0.05) and systolic blood pressure (r = 0.63, p < 0.01) in Ob-MS. Conclusion: These results support the hypothesis that there is an association between circulating resistin and childhood obesityrelated inflammatory and cardiometabolic events. (C) 2013 S. Karger GmbH, Freiburg
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