期刊
OBESITY
卷 22, 期 9, 页码 2039-2046出版社
WILEY
DOI: 10.1002/oby.20815
关键词
-
资金
- Arizona Biomedical Research Commission
- Arizona Alzheimer's Research Consortium (Department of Health Services, Arizona) [HB 2354]
- Evelyn F. McKnight Brain Institute
- National Institute on Aging (Arizona Alzheimer's Disease Core Center) [P30 AG19610]
- National Institute on Neurologic Disorder and Stroke [RO1 NS044107]
Objective: To assess whether the pattern of diffusion changes among a cohort of individuals showing BMI-related increases in white matter volume reflects healthy expansion of myelin or damaged white matter. Methods: Diffusion MRI measures (axial, radial, and fractional anisotropy) were obtained from 94 females, aged 52-92. Relationships between BMI and diffusion measures were assessed controlling for age, hypertension, and diabetes status using general linear modeling. Associations between diffusion measures and cognitive status (memory, executive functions, and visuomotor speed) were assessed using multiple regressions, controlling for age, education, hypertension, and diabetes status. Results: Higher levels of BMI were associated with lower axial diffusion in frontal, temporal, parietal, internal capsule, and cerebellar white matter. Lower fractional anisotropy was observed in bilateral temporal white matter and the right corticospinal tract, with higher radial diffusion in temporal and temporoparietal white matter. Importantly, diffusion measures predicted reductions in executive functioning, memory, and visuomotor speed. Conclusions: The pattern of diffusion changes in regions of white matter showing BMI-related volume increases are not due to expansion of normal myelin, but instead suggests damage to white matter that has important consequences for cognitive functioning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据