期刊
OBESITY
卷 22, 期 5, 页码 1373-1379出版社
WILEY-BLACKWELL
DOI: 10.1002/oby.20695
关键词
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资金
- Swedish Research Council [J_A 2006-6555, 2012-1727, 2012-2215, PS 2010-2847, JJC 2011-2349, UR K2012-55X22081-01-3, HA K2013-64X-08268-26-3]
- Swedish Heart-Lung Foundation
- Marianne and Marcus Wallenberg Foundation
- Dalarna University
- Uppsala University
- Karolinska Institutet Research Foundations
- Fredrik and Ingrid Thuring Foundation
- Osterman's and Westman's Foundations
- Strategic Research Programme in Diabetes at Karolinska Institutet (Swedish Research Council) [2009-1068]
Objective: The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population. Methods: Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual-energy X-ray absorptiometry and magnetic resonance imaging, were assessed in three community-based cohorts: ULSAM, n5790, mean age 78 years; PIVUS, n51003, mean age 70 years, women 50%; and the NORDIET-trial, n586, mean age 53 years, women 63%. Participants were re-examined after 5 years (PIVUS, n5804) or following a 6-week randomized controlled dietary intervention (NORDIET). Results: PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (P< 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (P< 0.001). Conclusions: These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.
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