期刊
OBESITY
卷 22, 期 3, 页码 950-956出版社
WILEY
DOI: 10.1002/oby.20598
关键词
-
资金
- NIH [R01 DK082610, R01 DK079169, 1R01 DK088972, P01 HL045522, R37 MH059490]
- National Center for Research Resources [S10 RR029392]
- Research Facilities Improvement Program [C06 RR013556]
- National Center for Research Resources of the National Institutes of Health [C06 RR017515]
- National Health and Medical Research Council of Australia
- OIS Program of the Victorian Government
Objective: Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods: Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results: After adjusting for age and sex interactions, body mass index, homeostasis model of assessment- insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18: 0, 20: 0, 22: 0, and 24: 1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31: 1 and 41: 1) were also associated with WC. Conclusions: Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.
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