期刊
OBESITY
卷 18, 期 2, 页码 274-281出版社
WILEY
DOI: 10.1038/oby.2009.229
关键词
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资金
- NIH [R01 DK 49779, R01 DK51684]
- General Clinical Research Center [M01-RR00032]
- Clinical Nutrition Research Unit [P30-DK56336]
- UaB University-wide Clinical Nutrition Research Cente
The purpose of this study was to determine independent relationships of intra-abdominal adipose tissue (IAAT), leg fat, and aerobic fitness with blood lipids and insulin sensitivity (S-i) in European-American (EA) and African-American (AA) premenopausal women. Ninety-three EA and ninety-four AA with BMI between 27 and 30 kg/m(2) had IAAT by computed tomography, total fat and leg fat by dual-energy X-ray absorptiometry, aerobic fitness by a graded exercise test, African admixture (AFADM) by ancestry informative markers, blood lipids by the Ektachem DT system, and S-i by glucose tolerance test. Independent of age, aerobic fitness, AFADM, and leg fat, IAAT was positively related to low-density lipoprotein-cholesterol (LDL-C), cholesterol-high-density lipoprotein (HDL) ratio, triglycerides (TGs), and fasting insulin (standardized beta varying 0.16-0.34) and negatively related to HDL-cholesterol (HDL-C) and S-i (standardized beta-0.15 and -0.25, respectively). In contrast, independent of age, aerobic fitness, AFADM, and IAAT, leg fat was negatively related to total cholesterol, LDL-C, cholesterol-HDL ratio, TGs, and fasting insulin (standardized beta varying -0.15 to -0.21) and positively related to HDL-C and S-i (standardized beta 0.16 and 0.23). Age was not independently related to worsening of any blood lipid but was related to increased S-i (standardized beta for S-i 0.25, insulin -0.31). With the exception of total cholesterol and LDL-C, aerobic fitness was independently related to worsened blood lipid profile and increased S-i (standardized beta varying 0.17 to -0.21). Maintenance of favorable fat distribution and aerobic fitness may be important strategies for healthy aging, at least in premenopausal EA and AA women.
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