期刊
OBESITY
卷 16, 期 6, 页码 1454-1456出版社
WILEY
DOI: 10.1038/oby.2008.213
关键词
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资金
- NIA NIH HHS [R01 AG017474-01A1, R01 AG017474, AG-15389, T32 AG000268, AG-17474, R01 AG015389, R01 AG015389-02] Funding Source: Medline
We investigated the association between soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels and obesity in older women. Fifty-one postmenopausal women ( 10 lean, 22 overweight, and 19 obese) were included in this small retrospective analysis. Plasma sLOX-1 levels were measured using a chemiluminescent enzyme-linked immunoassay. Plasma levels of sLOX-1 were significantly higher in obese women ( 55.33 +/- 4.49 pg/ml) compared to lean ( 30.91 +/- 6.19 pg/ml, P = 0.002) and overweight women ( 38.31 +/- 4.18 pg/ml, P = 0.017). Plasma sLOX-1 levels were positively associated with body weight, BMI, total body fat, and trunk fat. The relationship between sLOX-1 and BMI was attenuated after adjustment for age, hormone replacement therapy, and body fat. In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue.
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