期刊
OBESITY
卷 16, 期 2, 页码 348-355出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/oby.2007.65
关键词
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资金
- NCI NIH HHS [K07 CA124905, K07 CA124905-01A1] Funding Source: Medline
- NICHD NIH HHS [P01 HD031921, P01 HD 31921] Funding Source: Medline
- NIDA NIH HHS [K23 DA 017261, K23 DA017261] Funding Source: Medline
- NINDS NIH HHS [R01 NS049067, NS 049067] Funding Source: Medline
Objective: This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as adolescents transition into young adulthood. Interactions with gender and race/ethnicity were also examined. Methods and Procedures: Participants were a subsample of individuals from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. The sample analyzed included a subset of 1,584 unrelated individuals with genotype data. Multiple logistic regressions were conducted to evaluate the associations between genotypes and obesity (BMI > 29.9) or overweight + obese combined (BMI >= 25) with normal weight (BMI = 18.5-24.9) as a referent. Linear regression models were used to examine change in BMI from adolescence to young adulthood. Results: Significant associations were found between SLC6A4 5HTTLPR and categories of BMI, and between MAOA promoter variable number tandem repeat (VNTR) among men and categories of BMI. Stratified analyses revealed that the association between these two genes and excess BMI was significant for men overall and for white and Hispanic men specifically. Linear regression models indicated a significant effect of SLC6A4 5HTTLPR on change in BMI from adolescence to young adulthood. Discussion: Our findings lend further support to the involvement of genes implicated in dopamine and serotonin regulation on energy balance.
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