期刊
NUTRITIONAL NEUROSCIENCE
卷 17, 期 2, 页码 72-80出版社
MANEY PUBLISHING
DOI: 10.1179/1476830513Y.0000000076
关键词
Bayley scales; Infant neurodevelopment; Mexico; Molybdenum; Prenatal exposure
资金
- National Council of Science and Technology of Mexico (CONACyT) [41708, 31034-M, 13915]
- South-South Collaboration Program pertaining to the Fogarty International Center of the National Institutes of Health of Mount Sinai School of Medicine/Queens College International Training and Research in Environmental and Occupational Health Program [D43TW00640]
Objective: To evaluate the association between prenatal exposure to molybdenum (Mo) and infant neurodevelopment during the first 30 months of life. Methods: We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the products of uncomplicated pregnancies with no perinatal asphyxia, with a weight of >= 2 kg at birth, and whose mothers had no history of chronic illnesses. These women were monitored before, during, and after the pregnancy. For each of these children a maternal urine sample was available for at least one trimester of pregnancy, and urine Mo levels were determined by electrothermal atomic absorption spectrometry. Neurodevelopment was evaluated using the psychomotor (PDI) and mental development indices (MDI) of the Bayley scale. Association between prenatal exposure to Mo and infant neurodevelopment was estimated using generalized mixed effect models. Results: The average urinary concentrations of Mo adjusted for creatinine varied between 45.6 and 54.0 mu g/g of creatinine at first and third trimester, respectively. For each doubling increase of Mo (mu g/g creatinine) during the third trimester of pregnancy, we observed a significant reduction on PDI (beta = -0.57 points; P = 0.03), and no effect on MDI (beta = 0.07 points; P = 0.66). Discussion: As this is the first study that suggests a potential negative association between prenatal Mo exposure and infant neurodevelopment, these results require further confirmation.
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