期刊
NUTRITIONAL NEUROSCIENCE
卷 12, 期 5, 页码 226-232出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/147683009X423418
关键词
neural stem cells; folate; proliferation; apoptosis; extracellular signal-regulated kinase
资金
- National Natural Science Foundation of China [30571563, 30771797]
- Tianjin Municipal Education Commission, China [20070208]
Cellular events for neural progenitor cells, such as proliferation and differentiation, are regulated by multiple intrinsic and extrinsic cell signals. Folate plays central roles in central nervous system development, so folate, as an extrinsic signal, may affect neural stem cell (NSC) proliferation and differentiation. In this study, we have investigated the effect of folate on extracellular signal-regulated kinase (ERK1/2) phosphorylation, cell proliferation and apoptosis in fetal NSCs. The results showed that treatment of neurospheres with folate increased ERK1/2 phosphorylation and cell proliferation in a concentration-dependent manner. Folate also decreased the percentage of apoptotic cells. All of these effects of folate were prevented by a selective inhibitor (U0126) of mitogen-activated/ERK kinase 1/2. In conclusion, fetal NSCs respond to folate with ERK1/2 phosphorylation, cell proliferation and decreased apoptosis. This mechanism may mediate the regulation by folate of neurogenesis in the central nervous system.
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