期刊
NUTRITION REVIEWS
卷 70, 期 5, 页码 257-265出版社
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2012.00476.x
关键词
antioxidants; free radicals; oxidative damage; oxidative stress; redox
资金
- Tan Chin Tuan Foundation
This article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains uncertain, with cancer and neurodegenerative disease being likely exceptions. Even in diseases in which ROS are involved there has been little progress in developing effective antioxidant treatments. Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in vivo (as revealed by robust biomarkers). However, some strategies that are known to delay disease onset may act, at least in part, by decreasing oxidative damage levels. Nevertheless, far more is known today about endogenous antioxidant defenses and how they are regulated, which has led to a deeper understanding of how some ROS can act as signaling molecules. Increasing endogenous antioxidant levels (e.g., by supplying pro-oxidants) may be a better approach to therapeutics and disease prevention than consuming large doses of dietary antioxidants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据