期刊
NUTRITION REVIEWS
卷 68, 期 3, 页码 168-177出版社
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2010.00273.x
关键词
anthocyanins; berries; inflammation; lipid peroxidation; nitric oxide
资金
- University of Oklahoma Health Sciences Center General Clinical Research Center [M01-RR14467]
- National Center for Research Resources, and the National Institutes of Health
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR014467] Funding Source: NIH RePORTER
Berries are a good source of polyphenols, especially anthocyanins, micronutrients, and fiber. In epidemiological and clinical studies, these constituents have been associated with improved cardiovascular risk profiles. Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism. Benefits were seen in healthy subjects and in those with existing metabolic risk factors. Underlying mechanisms for these beneficial effects are believed to include upregulation of endothelial nitric oxide synthase, decreased activities of carbohydrate digestive enzymes, decreased oxidative stress, and inhibition of inflammatory gene expression and foam cell formation. Though limited, these data support the recommendation of berries as an essential fruit group in a heart-healthy diet. (C) 2010 International Life Sciences Institute
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