期刊
NUTRITION REVIEWS
卷 66, 期 9, 页码 487-505出版社
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2008.00082.x
关键词
child development; DALYs (disability adjusted life years); diarrhea; malabsorption; malnutrition
资金
- NIH (NIAID ICIDR) [U01 AI 26512]
- ApoE RO1 [RO1 HD053131]
- MARCE [U54 A1057168]
- Fogarty International Center [D43 TW0006578]
- Brazilian CAPES Agency
- US-Brazil Higher Education Consortium Program
- National Institute of Child Health and Human Development (NICHD) [K12-HD000850]
Malnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate-limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long-term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea-malnutrition cycle so children may develop their full potential. (C) 2008 International Life Sciences Institute.
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