期刊
NUTRITION REVIEWS
卷 66, 期 10, 页码 S116-S124出版社
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2008.00094.x
关键词
apoptosis; calcitriol; cell cycle; hyperplasia; signal transduction; transcription factors
Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell-specific factors that influence responsiveness to vitamin D. (C) 2008 International Life Sciences Institute.
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