期刊
NUTRITION REVIEWS
卷 66, 期 10, 页码 S178-S181出版社
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2008.00102.x
关键词
calcium absorption; cancer; falls; fractures; hypercalcemia; immune function; insulin response
The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day). (C) 2008 International Life Sciences Institute.
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