期刊
NUTRITION RESEARCH REVIEWS
卷 25, 期 1, 页码 150-161出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954422412000054
关键词
Adiposity; Obesity; Body fat distribution; Metabolic phenotypes
资金
- UK MRC (Medical Research Council)
- NIHR (National Institute for Health Research) Biomedical Research Centre
- MRC [MC_U120061305] Funding Source: UKRI
- Medical Research Council [MC_U120061305] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10112] Funding Source: researchfish
Excess body adiposity, especially abdominal obesity and ectopic fat accumulation, are key risk factors in the development of a number of chronic diseases. The advent of in vivo imaging methodologies that allow direct assessment of total body fat and its distribution have been pivotal in this process. They have helped to identify a number of sub-phenotypes in the general population whose metabolic risk factors are not commensurate with their BMI. At least two such sub-phenotypes have been identified: subjects with normal BMI, but excess intra-abdominal (visceral) fat (with or without increased ectopic fat) and subjects with elevated BMI (> 25 kg/m(2)) but low visceral and ectopic fat. The former sub-phenotype is associated with adverse metabolic profiles, while the latter is associated with a metabolically normal phenotype, despite a high BMI. Here, examples of these phenotypes are presented and the value of carrying out enhanced phenotypical characterisation of subjects in interventional studies discussed.
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