期刊
NUTRITION RESEARCH REVIEWS
卷 25, 期 1, 页码 130-141出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954422412000029
关键词
Calcium; Vitamin D; Obesity; Apoptosis; 1,25-Dihydroxyvitamin D-3; Intracellular Ca2+; Adipocytes
资金
- United States Department of Agriculture [SD00294-H, SD00H167-061HG, 2009-35200-05008]
- NIFA [582614, 2009-35200-05008] Funding Source: Federal RePORTER
New and more effective nutritional measures are urgently needed for the prevention of obesity. The role of Ca and vitamin D in obesity has been recently implicated. Low Ca intake and low vitamin D status have been linked with an increased risk of obesity in epidemiological studies; however, clinical intervention trials designed to test this association have produced controversial results. The suggested anti-obesity mechanisms of Ca and vitamin D include the regulation of adipocyte death (apoptosis), adipogenesis and lipid metabolism. Dietary Ca has been also shown to increase faecal fat excretion. The potential role of Ca and vitamin D in shifting energy balance towards a more negative state is an area of considerable interest. Ultimately, a review of recent research findings does not allow the reaching of a definitive conclusion that increasing Ca intake and rising vitamin D status will influence fat mass and body weight or decrease the risk of obesity and overweight.
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