期刊
NUTRITION RESEARCH
卷 31, 期 3, 页码 190-196出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nutres.2011.02.003
关键词
Cranberry; Oxidized LDL; Malondialdehyde; Plasma antioxidant capacity; Metabolic syndrome; Women
资金
- Cranberry Institute
- Wisconsin Cranberry Board, Inc. (MA, USA)
- College of Human Environmental Sciences, Dean's Research Incentive, at Oklahoma State University
- University of Oklahoma Health Sciences Center General Clinical Research Center [M01-RR14467]
- National Center for Research Resources, National Institutes of Health
Cranberries, high in polyphenols, have been associated with several cardiovascular health benefits, although limited clinical trials have been reported to validate these findings. We tested the hypothesis that commercially available low-energy cranberry juice (Ocean Spray Cranberries, Inc, Lakeville-Middleboro, Mass) will decrease surrogate risk factors of cardiovascular disease, such as lipid oxidation, inflammation, and dyslipidemia, in subjects with metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, participants identified with metabolic syndrome (n = 15-16/group) were assigned to 1 of 2 groups: cranberry juice (480 mL/day) or placebo (480 mL/day) for 8 weeks. Anthropometrics, blood pressure measurements, dietary analyses, and fasting blood draws were conducted at screen and 8 weeks of the study. Cranberry juice significantly increased plasma antioxidant capacity (1.5 +/- 0.6 to 2.2 +/- 0.4 mu mol/L [means +/- SD], P < .05) and decreased oxidized low-density lipoprotein and malondialdehyde (120.4 +/- 31.0 to 80.4 +/- 34.6 U/L and 3.4 +/- 1.1 to 1.7 +/- 0.7 mu mol/L, respectively [means +/- SD], P < .05) at 8 weeks vs placebo. However, cranberry juice consumption caused no significant improvements in blood pressure, glucose and lipid profiles, C-reactive protein, and interleukin-6. No changes in these parameters were noted in the placebo group. In conclusion, low-energy cranberry juice (2 cups/day) significantly reduces lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. (C) 2011 Elsevier Inc. All rights reserved.
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