期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 23, 期 3, 页码 250-256出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2012.02.006
关键词
Dietary patterns; Coronary heart disease; Stroke; Principal component analysis; k-Means cluster analysis
资金
- Europe against Cancer Program of the European Commission (SANCO)
- Dutch Ministry of Health
- Dutch Cancer Society
- Netherlands Organisation for Health Research and Development (ZonMW)
- World Cancer Research Fund (WCRF)
- Dutch Research Council (NWO-ZonMw) [40-00812-98-10040]
Background and aims: Studies comparing dietary patterns derived from different a posteriori methods in view of predicting disease risk are scarce. We aimed to explore differences between dietary patterns derived from principal component-(PCA) and k-means cluster analysis (KCA) in relation to their food group composition and ability to predict CHD and stroke risk. Methods and results: The study was conducted in the EPIC-NL cohort that consists of 40,011 men and women. Baseline dietary intake was measured using a validated food-frequency questionnaire. Food items were consolidated into 31 food groups. Occurrence of CHD and stroke was assessed through linkage with registries. After 13 years of follow-up, 1,843 CHD and 588 stroke cases were documented. Both PCA and KCA extracted a prudent pattern (high intakes of fish, high-fiber products, raw vegetables, wine) and a western pattern (high consumption of French fries, fast food, low-fiber products, other alcoholic drinks, soft drinks with sugar) with small variation between components and clusters. The prudent component was associated with a reduced risk of CHD (HR for extreme quartiles: 0.87; 95%-CI: 0.75-1.00) and stroke (0.68; 0.53-0.88). The western component was not related to any outcome. The prudent cluster was related with a lower risk of CHD (0.91; 0.82-1.00) and stroke (0.79; 0.67-0.94) compared to the western cluster. Conclusion: PCA and KCA found similar underlying patterns with comparable associations with CHD and stroke risk. A prudent pattern reduced the risk of CHD and stroke. (C) 2012 Elsevier B. V. All rights reserved.
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