期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 22, 期 4, 页码 362-368出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2010.07.015
关键词
Methionine adenosyltransferase; Dietary fatty acids; Plasma homocysteine
资金
- China Scholarship Council
- National Institutes of Health, National Institute on Aging [5P01AG023394-02]
- NIH/NHLBI [HL54776, HL078885]
- U.S. Department of Agriculture Research Service [53-K06-5-10, 58-1950-9-001]
Background and Aim: Dietary n-3 polyunsaturated fatty acids (PUFAs) are associated with decreased plasma homocysteine (Hcy), an important biomarker for cardiovascular disease. The S-adenosylmethionine synthetase type-1 (MAT1A), an essential enzyme in the conversion of methionine to S-adenosylmethionine, plays a key role in homocysteine metabolism. This study investigated the interaction between dietary fatty acids and MAT1A genotypes on plasma Hcy concentrations among Boston Puerto Ricans. Methods and Results: Plasma Hcy and MAT1A genotypes were determined in 994 subjects of the Boston Puerto Rican Health Study. Dietary fatty acid intakes were assessed by interviews using a questionnaire adapted from the NCI/Block food frequency form. Result: In the cross-sectional analysis, genetic variant MAT1A 3U1510 displayed a significant interaction with dietary n-3:n-6 PUFA ratio in determining plasma Hcy (p-value for interaction = 0.025). 3U1510G homozygotes had significantly lower plasma Hcy concentration than major allele homozygotes and heterozygotes (AA + AG) (p-value for trend = 0.019) when the n-3:n-6 ratio was >0.09. Two other MAT1A variants, d18777 and i15752, also showed significant interactions with different constituents of dietary fat influencing Hcy concentrations. Furthermore, haplotypes consisting of three variants displayed a strong interaction with n3:n6 ratio influencing Hcy concentrations. Conclusions: Our results suggest that MAT1A genotypes appear to modulate effects of dietary fat on plasma Hcy. Published by Elsevier B.V.
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