期刊
NUTRITION JOURNAL
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1475-2891-10-130
关键词
Randomized clinical trial; oats; beta-glucan; ethnicity; cholesterol
资金
- CreaNutrition
- Swedish Governmental Agency for Innovations Systems (VINNOVA)
- Agriculture and Agri-Foods Canada
Background: There is increasing global acceptance that viscous soluble fibers lower serum LDL cholesterol (LDL-C), but most evidence for this comes from studies in Caucasians. To see if oat beta-glucan lowers LDL-C in Caucasians and non-Caucasians we conducted a post-hoc analysis of the results of a randomized, controlled, double-blind, multi-center clinical trial whose primary aim was to determine if molecular-weight (MW) influenced the LDL-C-lowering effect of oat beta-glucan. Results: Caucasian and non-Caucasian subjects with LDL-C-C >= 3.0 and <= 5.0 mmol/L (n = 786 screened, n = 400 ineligible, n = 19 refused, n = 367 randomized, n = 345 completed, n = 1 excluded for missing ethnicity) were randomly assigned to consume cereal containing wheat-fiber (Control, n = 74: 13 Caucasian: non-Caucasian) or 3 g high-MW (3H, 2,250,000 g/mol, n = 67: 19), 4 g medium-MW (4 M, 850,000 g/mol, n = 50: 17), 3 g medium-MW (3M, 530,000 g/mol, n = 54: 9) or 4 g low-MW (4 L, 210,000 g/mol, n = 51: 12) oat beta-glucan daily for 4 weeks. LDL-C after 4 weeks was influenced by baseline LDL-C (p < 0.001) and treatment (p = 0.003), but not ethnicity (p = 0.74). In all subjects, compared to control, 3 H, 4 M and 3 M reduced LDL-C significantly by 4.8 to 6.5%, but 4 L had no effect. Compared to control, the bioactive oat b-glucan treatments (3H, 4M and 3M) reduced LDL-C by a combined mean (95% CI) of 0.18 (0.06, 0.31) mmol/L (4.8%, n = 171, p = 0.004) in Caucasians, a value not significantly different from the 0.37 (0.09, 0.65) mmol/L (10.3%, n = 45, p = 0.008) reduction in non-Caucasians. Conclusion: We conclude that oat beta-glucan reduces LDL-C in both Caucasians and non-Caucasians; there was insufficient power to determine if the magnitude of LDL-C-lowering differed by ethnicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据