期刊
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
卷 62, 期 7, 页码 931-937出版社
LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS
DOI: 10.1080/01635581.2010.509536
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资金
- NIH [CA120915, CA122474, CA133021]
- NATIONAL CANCER INSTITUTE [R01CA133021, R01CA120915, R01CA122474] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES005022] Funding Source: NIH RePORTER
Extracts of green tea and green tea polyphenols have exhibited inhibitory effects against the formation and development of tumors at different organ sites in animals. These include animal models for skin, lung, oral cavity, esophagus, stomach, intestine, colon, liver, pancreas, bladder, mammary gland, and prostate cancers. In addition to suppressing cell proliferation, promoting apoptosis, and modulating signaling transduction, green tea polyphenols, especially (-)-epigallocatechin-3-gallate, also inhibit cell invasion, angiogenesis, and metastasis. This article reviews data on the cancer preventive activities of green tea polyphenols, possible mechanisms involved, and the relationship between green tea consumption and human cancer risk.
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