ONE-POT PALLADIUM-CATALYZED LIGAND- AND METAL-OXIDANT-FREE AEROBIC OXIDATIVE ISOCYANIDE INSERTION LEADING TO 2-AMINO-SUBSTITUTED-4(3H)-QUINAZOLINONES

An efficient, ligand- and metal-oxidant-free, one-pot, cascade aerobic oxidative, palladium-catalyzed, multicomponent reaction has been developed through isocyanide insertion of less active secondary amide and aromatic amine, which leads to 2-amino-substituted-4(3H)-quinazolinones. This approach proves to be one of the simplest methods for the synthesis of this class of valuable bioactive heterocyclic scaffolds.