期刊
SYNTHETIC COMMUNICATIONS
卷 45, 期 17, 页码 1977-1985出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2015.1056796
关键词
Antibacterial activity; antifungal activity; click reaction; 1; 4-disubstituted 1; 2; 3-bistriazoles
A convenient synthesis of some new 1,4-disubstituted 1,2,3-bistriazoles (3a-3f, 4a-4f, 6a-6b, 7a-7b) is reported via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of various terminal alkynes with 1,4-bis(azidomethyl)benzene and 1,6-diazidohexane. The synthesized compounds were characterized by spectral techniques including infrared, H-1 NMR, C-13 NMR, and high-resolution mass spectrometry and tested in vitro for antimicrobial potential against Bacillus subtilis and Staphylococcus aureus (Gram-positive bacteria), Pseudomonas aeruginosa and Escherichia coli (Gram-negative bacteria), and Candida albicans and Aspergillus niger (fungi). Among the synthesized 1,4-disubstituted 1,2,3-bistriazoles, compounds 6a, 6b, and 7b displayed excellent antimicrobial potential against most of the tested strains.
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