Synthesis of -Hydroxycarboxylic Acid Anilides via Copper-Catalyzed C-N Coupling of -Hydroxyamides with Aryl Halides

The synthesis of highly important alpha-hydroxycarboxylic acid anilides via copper-catalyzed chemoselective C-N coupling reactions of -hydroxyamides and aryl halides is described. This highly selective N-arylation process demonstrates wide substrate scope, cost savings and easy operation. In addition, the chirality of l-3-phenyllactamide is preserved during the reaction.