Synthesis, Chiral Resolution, and Absolute Configuration of Functionalized Troger's Base Derivatives: Part III

Eleven different derivatives of Troger's base were synthesized and successfully resolved by (recycling) HPLC on chiral stationary (S,S)-Whelk-O1 or CHIRALPAK IA phase on a (semi-) preparative scale or synthesized in enantiomerically pure form. The absolute configuration was determined by X-ray crystal structure analysis, comparison of the quantum chemically calculated circular dichroism spectra with the experimental spectra, or comparison of specific rotations with literature data.