期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 29, 期 7, 页码 542-546出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2010.487507
关键词
5-Azidouracil nucleosides; benzylamination; azidation
资金
- ICSN/CNRS
Previously reported syntheses of the photoaffinity label 5-azido-2'-deoxyuridine are rather inefficient and involve the tedious preparation of a 5-nitro intermediate. To overcome these inconveniences, we have developed a new approach from the commercially available 5-bromo-2'-deoxyuridine nucleoside. Our synthetic route makes use of a benzylamination reduction sequence. Using this strategy, the 5-azido-2'-deoxyuridine photolabel is prepared in three steps and quantitative yields.
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