期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 27, 期 9, 页码 1034-1044出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770802271771
关键词
anti-HIV activity; acyclic C-nucleosides; microwave-assisted synthesis; triazolo-thiadiazoles and -thiadiazines; sulphonamides; carboxamides
A new series of acyclic C-nucleosides 1',2'-O-isopropylidene-D-ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upon acid hydrolysis, afforded the free nucleosides 16-18. The new synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound 7 was also screened against a panel of tumor cell lines consisting of CD4 human T-cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据