期刊
NUCLEIC ACIDS RESEARCH
卷 43, 期 D1, 页码 D784-D788出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gku1166
关键词
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资金
- Science without borders program - CNPq (National Council for Scientific and Technological Development-Brazil)
- National Council on Science and Technology of Mexico [FOINS-CONACYT-217830-R]
- University of Liverpool Library
- National Institutes of Health Research (NIHR) [II-LB-0313-20008] Funding Source: National Institutes of Health Research (NIHR)
- Epilepsy Research UK [P1105] Funding Source: researchfish
- National Institute for Health Research [II-LB-0313-20008] Funding Source: researchfish
It has been 12 years since the Allele Frequency Net Database (AFND; http://www.allelefrequencies.net) was first launched, providing the scientific community with an online repository for the storage of immune gene frequencies in different populations across the world. There have been a significant number of improvements from the first version, making AFND a primary resource for many clinical and scientific areas including histocompatibility, immunogenetics, pharmacogenetics and anthropology studies, among many others. The most widely used part of AFND stores population frequency data (alleles, genes or haplotypes) related to human leukocyte antigens (HLA), killer-cell immunoglobulin-like receptors (KIR), major histocompatibility complex class I chain-related genes (MIC) and a number of cytokine gene polymorphisms. AFND now contains >1400 populations from more than 10 million healthy individuals. Here, we report how the main features of AFND have been updated to include a new section on 'HLA epitope' frequencies in populations, a new section capturing the results of studies identifying HLA associations with adverse drug reactions (ADRs) and one for the examination of infectious and autoimmune diseases associated with KIR polymorphisms-thus extending AFND to serve a new user base in these growing areas of research. New criteria on data quality have also been included.
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