期刊
SYNLETT
卷 27, 期 5, 页码 749-753出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561284
关键词
photoredox catalysis; asymmetric catalysis; visible light; perfluoroalkylation; radical reaction; electron catalysis
资金
- German Research Foundation [ME 1805/11-1]
- Philipps-Universitat Marburg
- China Scholarship Council
A visible-light-activated enantioselective radical perfluoroalkylation of 2-acyl imidazoles with perfluoroalkyl iodides (CF3I, C3F7I, C4F9I, C6F13I, C8F17I and C10F21I) and perfluorobenzyl iodide at the -position of the carbonyl group is reported. Enantioselectivities with up to >99.5% ee are achieved. The process uses a dual-function chiral Lewis acid/photoredox catalyst at loadings of 2-4mol% and constitutes a redox-neutral, electron-catalyzed reaction that proceeds via intermediate perfluoroalkyl radicals.
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