期刊
NUCLEIC ACIDS RESEARCH
卷 42, 期 9, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gku181
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资金
- Wellcome Trust [WT091310, WT098051]
- European Community
- National Institutes of Health [R01HD071180, R01AG030678]
- MRC [G0600717] Funding Source: UKRI
- Medical Research Council [G0600717, MC_UU_12012/5/B, G0600717B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10380, NF-SI-0510-10268, NF-SI-0513-10109] Funding Source: researchfish
Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.
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