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ONCOGENE (2013)
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
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BRIEFINGS IN FUNCTIONAL GENOMICS (2012)
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Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
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CELL (2011)
Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains
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CELL (2011)
The super elongation complex (SEC) and MLL in development and disease
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GENES & DEVELOPMENT (2011)
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways
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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
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Structural and Biochemical Insights into MLL1 Core Complex Assembly
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Identification and Characterization of a Novel Human PP1 Phosphatase Complex
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An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain
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EMBO JOURNAL (2009)
On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex
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MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription
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Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II
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MOLECULAR CELL (2009)
The human trithorax protein hASH2 functions as an oncoprotein
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CANCER RESEARCH (2008)
WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS
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MOLECULAR AND CELLULAR BIOLOGY (2008)
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex
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Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution:: a critical regulatory circuit lost in leukemogenic MLL fusions
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GENES & DEVELOPMENT (2007)
PTIP associates with MLL3-and MLL4-containing histone H3 lysine 4 methyltransferase complex
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
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Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2
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MOLECULAR BIOLOGY OF THE CELL (2007)
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
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MOLECULAR AND CELLULAR BIOLOGY (2007)
Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression
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GENES & DEVELOPMENT (2006)
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Molecular recognition of histone H3 by the WD40 protein WDR5
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development
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DEVELOPMENT (2006)
MLL associates specifically with a subset of transcriptionally active target genes
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The set1 methyltransferase orwoses IpI1 aurora kinase functions in chromosome segregation
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CELL (2005)
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CELL (2005)
Global and Hox-specific roles for the MLL1 methyltransferase
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
MLL: a histone methyltransferase disrupted in leukemia
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1
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BRCT domain-containing protein PTIP is essential for progression through mitosis
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
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