相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
Sanjib Dutta et al.
ACS CHEMICAL BIOLOGY (2013)
Structure-Based Redesign of the Binding Specificity of Anti-Apoptotic Bcl-xL
T. Scott Chen et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Optimal codon randomization via mathematical programming
Yuval Nov et al.
JOURNAL OF THEORETICAL BIOLOGY (2013)
Precision is essential for efficient catalysis in an evolved Kemp eliminase
Rebecca Blomberg et al.
NATURE (2013)
Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis
Sabrina Kille et al.
ACS SYNTHETIC BIOLOGY (2013)
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
Timothy A. Whitehead et al.
NATURE BIOTECHNOLOGY (2012)
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
Olga Khersonsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Optimization of Combinatorial Mutagenesis
Andrew S. Parker et al.
JOURNAL OF COMPUTATIONAL BIOLOGY (2011)
Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution
Olga Khersonsky et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
Mihai L. Azoitei et al.
SCIENCE (2011)
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
Sarel J. Fleishman et al.
SCIENCE (2011)
Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library
Shaun M. Lippow et al.
CHEMISTRY & BIOLOGY (2010)
Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series
Olga Khersonsky et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Optimizing nucleotide sequence ensembles for combinatorial protein libraries using a genetic algorithm
Roger A. Craig et al.
NUCLEIC ACIDS RESEARCH (2010)
Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles
Benjamin D. Allen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Engineering a protein-protein interface using a computationally designed library
Gurkan Guntas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries
Roberto A. Chica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Combinatorial codons: A computer program to approximate amino acid probabilities with biased nucleotide usage
Ethan Wolf et al.
PROTEIN SCIENCE (2010)
Macromolecular modeling with Rosetta
Rhiju Das et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2008)
Addressing the numbers problem in directed evolution
Manfred T. Reetz et al.
CHEMBIOCHEM (2008)
Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions
Manfred T. Reetz et al.
CHEMICAL COMMUNICATIONS (2008)
Directed enzyme evolution via small and effective neutral drift libraries
Rinkoo D. Gupta et al.
NATURE METHODS (2008)
GLUE-IT and PEDEL-AA: new programmes for analyzing protein diversity in randomized libraries
Andrew E. Firth et al.
NUCLEIC ACIDS RESEARCH (2008)
Incorporating Synthetic Oligonucleotides via Gene Reassembiv (ISOR): a versatile tool forgenerating targeted libraries
Asael Herman et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2007)
High-affinity single-domain binding proteins with a binary-code interface
Akiko Koide et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function
Thomas P. Treynor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library
Marco A. Mena et al.
NATURE BIOTECHNOLOGY (2006)
Automated design of degenerate codon libraries
MA Mena et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2005)
FamClash: A method for ranking the activity of engineered enzymes
MC Saraf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
FA Fellouse et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A second-generation system for unbiased reading frame selection
ML Gerth et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2004)
User-friendly algorithms for estimating completeness and diversity in randomized protein-encoding libraries
WM Patrick et al.
PROTEIN ENGINEERING (2003)
Combining computational and experimental screening for rapid optimization of protein properties
RJ Hayes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Designing gene libraries from protein profiles for combinatorial protein experiments
W Wang et al.
NUCLEIC ACIDS RESEARCH (2002)
Native protein sequences are close to optimal for their structures
B Kuhlman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)