相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Telomere Maintenance as a Target for Drug Discovery
Vijay Sekaran et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
A Model of Smart G-Quadruplex Ligand
Romain Haudecoeur et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
Viktor Brabec et al.
CHEMICAL SCIENCE (2013)
Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
Jian Hu et al.
CELL (2012)
A three-state model of telomere control over human proliferative boundaries
Anthony J. Cesare et al.
CURRENT OPINION IN CELL BIOLOGY (2012)
Recent Developments in the Chemistry and Biology of G-Quadruplexes with Reference to the DNA Groove Binders
Akash K. Jain et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Optically pure, water-stable metallo-helical 'flexicate' assemblies with antibiotic activity
Suzanne E. Howson et al.
NATURE CHEMISTRY (2012)
Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake
Qianqian Yu et al.
PLOS ONE (2012)
Removal of Shelterin Reveals the Telomere End-Protection Problem
Agnel Sfeir et al.
SCIENCE (2012)
Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres
Yong Chen et al.
NATURE COMMUNICATIONS (2012)
Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions
Chuanqi Zhao et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer
Stephen Neidle
FEBS JOURNAL (2010)
DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity
Haijia Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
A Chiral Wedge Molecule Inhibits Telomerase Activity
Ken-ichi Shinohara et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal
Agnel Sfeir et al.
SCIENCE (2010)
G-quadruplex nucleic acids as therapeutic targets
Shankar Balasubramanian et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2009)
How Telomeres Solve the End-Protection Problem
Titia de Lange
SCIENCE (2009)
Targeting DNA
Jonathan B. Chaires et al.
BIOCHIMIE (2008)
G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
Carlo Leonetti et al.
CLINICAL CANCER RESEARCH (2008)
Telomeric 3′-overhang length is associated with the size of telomeres
Ruman Rahman et al.
EXPERIMENTAL GERONTOLOGY (2008)
Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA
Haijia Yu et al.
NUCLEIC ACIDS RESEARCH (2008)
A hitchhiker's guide to G-quadruplex ligands
David Monchaud et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
Use of competition dialysis in the discovery of G-quadruplex selective ligands
Patricia Ragazzon et al.
METHODS (2007)
Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae
Chien-Huang Liao et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
Erica Salvati et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Targeting the limitless replicative potential of cancer: The telomerase/telomere pathway
Lloyd Kelland
CLINICAL CANCER RESEARCH (2007)
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi et al.
NATURE (2007)
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
P. Phatak et al.
BRITISH JOURNAL OF CANCER (2007)
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction
Raphael Rodriguez et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells
Dennis Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin:: in vitro and in vivo studies in acute leukemia
T. Tauchi et al.
ONCOGENE (2006)
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells
Annamaria Biroccio et al.
EUROPEAN JOURNAL OF CANCER (2006)
G-quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells
H Tahara et al.
ONCOGENE (2006)
Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities
S Hanaoka et al.
PROTEIN SCIENCE (2005)
G-taff teLomere HPA: simple measurement of human single-stranded telomeric overhangs
H Tahara et al.
NATURE METHODS (2005)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
AJ Zaug et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Lipid modification of GRN163, an N3′ → P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
BS Herbert et al.
ONCOGENE (2005)
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
D Hockemeyer et al.
EMBO JOURNAL (2005)
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
AM Burger et al.
CANCER RESEARCH (2005)
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
H El-Daly et al.
BLOOD (2005)
T-loops and the origin of telomeres
T de Lange
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Loss of hPot1 function leads to telomere instability and a cut-like phenotype
T Veldman et al.
CURRENT BIOLOGY (2004)
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
C Leonetti et al.
MOLECULAR PHARMACOLOGY (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig et al.
MOLECULAR CELL (2004)
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition
OE Bechter et al.
CANCER RESEARCH (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
DNA damage foci at dysfunctional telomeres
H Takai et al.
CURRENT BIOLOGY (2003)
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways
T Tauchi et al.
ONCOGENE (2003)
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
J Haendeler et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
POT1 as a terminal transducer of TRF1 telomere length control
D Loayza et al.
NATURE (2003)
The structure of telomeric DNA
S Neidle et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2003)
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
SM Gowan et al.
MOLECULAR PHARMACOLOGY (2002)
Intramolecular DNA coiling mediated by metallosupramolecular cylinders: Differential binding of P and M helical enantiomers
I Meistermann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Senescence induced by altered telomere state, not telomere loss
J Karlseder et al.
SCIENCE (2002)
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
MY Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
IM Ward et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Paper: a cheap yet effective chiral stationary phase for chromatographic resolution of metallo-supramolecular helicates
MJ Hannon et al.
CHEMICAL COMMUNICATIONS (2001)
Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
KB Liu et al.
JOURNAL OF IMMUNOLOGY (2001)
Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang
KE Huffman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Involvement of 14-3-3 proteins in nuclear localization of telomerase
H Seimiya et al.
EMBO JOURNAL (2000)
Control of human telomere length by TRF1 and TRF2
A Smogorzewska et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
分享论文
