4.8 Article

Weak base pairing in both seed and 3′ regions reduces RNAi off-targets and enhances si/shRNA designs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

Aleksandra Helwak et al.

Article Biochemistry & Molecular Biology

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

Michael C. Bassik et al.

Review Biotechnology & Applied Microbiology

A dynamic perspective of RNAi library development

Qiuwei Pan et al.

TRENDS IN BIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay

Christof Fellmann et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs

David M. Garcia et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Biochemical Principles of Small RNA Pathways

Qinghua Liu et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)

Article Medicine, Research & Experimental

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

Dirk Grimm et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Mammalian microRNAs predominantly act to decrease target mRNA levels

Huili Guo et al.

NATURE (2010)

Review Biotechnology & Applied Microbiology

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

Aimee L. Jackson et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Medicine, Research & Experimental

RNAi-based therapeutics-current status, challenges and prospects

Katrin Tiemann et al.

EMBO MOLECULAR MEDICINE (2009)

Review Multidisciplinary Sciences

The promises and pitfalls of RNA-interference-based therapeutics

Daniela Castanotto et al.

NATURE (2009)

Review Cell Biology

Biogenesis of small RNAs in animals

V. Narry Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs

Shuo Gu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Experimental validation of the importance of seed complement frequency to siRNA specificity

Emily M. Anderson et al.

Article Biochemistry & Molecular Biology

Molecular basis for target RNA recognition and cleavage by human RISC

Stefan Ludwig Ameres et al.

Article Biochemistry & Molecular Biology

MicroRNA targeting specificity in mammals: Determinants beyond seed pairing

Andrew Grimson et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Position-specific chemical modification of siRNAs reduces off-target'' transcript silencing

Aimee L. Jackson et al.

Article Biochemical Research Methods

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

A Birmingham et al.

NATURE METHODS (2006)

Article Biotechnology & Applied Microbiology

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

AD Judge et al.

NATURE BIOTECHNOLOGY (2005)

Review Biochemistry & Molecular Biology

MicroRNAs: Genomics, biogenesis, mechanism, and function

DP Bartel

Article Multidisciplinary Sciences

Argonaute2 is the catalytic engine of mammalian RNAi

JD Liu et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Prediction of mammalian microRNA targets

BP Lewis et al.

Article Biochemistry & Molecular Biology

Functional siRNAs and rniRNAs exhibit strand bias

A Khvorova et al.

Article Biochemistry & Molecular Biology

Asymmetry in the assembly of the RNAi enzyme complex

DS Schwarz et al.

Article Biotechnology & Applied Microbiology

Expression profiling reveals off-target gene regulation by RNAi

AL Jackson et al.

NATURE BIOTECHNOLOGY (2003)

Article Cell Biology

siRNAs can function as miRNAs

JG Doench et al.

GENES & DEVELOPMENT (2003)

Article Cell Biology

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

PJ Paddison et al.

GENES & DEVELOPMENT (2002)

Article Multidisciplinary Sciences

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

SM Elbashir et al.

NATURE (2001)