期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 21, 页码 9593-9609出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt700
关键词
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资金
- National Institutes of Health [R21 DK082634, R01 CA107106, R01 GM62970]
- Ohio State University
H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. The biology of the linker histones is complex, as they are evolutionarily variable, exist in multiple isoforms and undergo a large variety of posttranslational modifications in their long, unstructured, NH2- and COOH-terminal tails. We review recent progress in understanding the structure, genetics and posttranslational modifications of linker histones, with an emphasis on the dynamic interactions of these proteins with DNA and transcriptional regulators. We also discuss various experimental challenges to the study of H1 and related proteins, including limitations of immunological reagents and practical difficulties in the analysis of posttranslational modifications by mass spectrometry.
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