期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 14, 页码 7144-7152出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt443
关键词
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资金
- Ministry of Science and Technology of China [2013CB530802, 2012CB720601, 2010CB945300]
- National Science Foundation of China [30970617, 21072189]
G-quadruplexes, four-stranded structures formed by Guanine-rich nucleic acids, are implicated in many physiological and pathological processes. G-quadruplex-forming sequences are abundant in genomic DNA, and G-quadruplexes have recently been shown to exist in the genome of mammalian cells. However, how G-quadruplexes are formed in the genomes remains largely unclear. Here, we show that G-quadruplex formation can be remotely induced by downstream transcription events that are thousands of base pairs away. The induced G-quadruplexes alter protein recognition and cause transcription termination at the local region. These results suggest that a G-quadruplex-forming sequence can serve as a sensor or receiver to sense remote DNA tracking activity in response to the propagation of mechanical torsion in a DNA double helix. We propose that the G-quadruplex formation may provide a mean for long-range sensing and communication between distal genomic locations to coordinate regulatory transactions in genomic DNA.
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