期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 W1, 页码 W165-W168出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt430
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资金
- Swiss National Science Foundation [PDFMA3-118375, 31003A-125350]
- Swiss Institute of Bioinformatics
- Swiss National Science Foundation (SNF) [31003A-125350] Funding Source: Swiss National Science Foundation (SNF)
MicroRNAs (miRNAs) posttranscriptionally repress the expression of protein-coding genes. Based on the partial complementarity between miRNA and messenger RNA pairs with a mandatory so-called 'seed' sequence, many thousands of potential targets can be identified. Our open-source software library, miRmap, ranks these potential targets with a biologically meaningful criterion, the repression strength. MiRmap combines thermodynamic, evolutionary, probabilistic and sequence-based features, which cover features from TargetScan, PITA, PACMIT and miRanda. Our miRmap web application offers a user-friendly and feature-rich resource for browsing precomputed miRNA target predictions for model organisms, as well as for predicting and ranking targets for user-submitted sequences. MiRmap web integrates sorting, filtering and exporting of results from multiple queries, as well as providing programmatic access, and is available at http://mirmap.ezlab.org.
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