期刊
NUCLEIC ACIDS RESEARCH
卷 42, 期 1, 页码 458-474出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt839
关键词
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资金
- Major State Basic Research Development Program of China (973 Program) [2011CB811300, 2010CB912801]
- National Natural Science Foundation of China [31100569, 30971630]
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist of similar to 22 nt and are involved in several biological processes by regulating target gene expression. MiR-138 has many biological functions and is often downregulated in cancers. Our results showed that overexpression of miR-138 downregulated target RMND5A (required for meiotic nuclear division 5 homolog A) and reduced Exportin-5 stability, which results in decreased levels of pre-miRNA nuclear export in HeLa cells. We also found that miR-138 could significantly inhibit HeLa cell migration by targeting RMND5A. Our study therefore identifies miR-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells.
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