期刊
SYNLETT
卷 27, 期 2, 页码 262-266出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1560644
关键词
Arabidopsis thaliana; novozyme 435; biocatalysis; flow; telescoped; HCN; cyanohydrins
资金
- Deutsche Forschungsgemeinschaft (DFG)
- EPSRC [EP/K009494/1, EP/K039520/1]
- Engineering and Physical Sciences Research Council [EP/K009494/1, EP/K039520/1] Funding Source: researchfish
An enantioselective preparation of O-acetylcyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas, and in-line stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.
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