期刊
NUCLEIC ACIDS RESEARCH
卷 40, 期 W1, 页码 W222-W227出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks363
关键词
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资金
- Czech Science foundation [GD301/09/H004, 303/09/1001, P303/12/P019, P208/12/G016]
- Ministry of Education of the Czech Republic [ME 08008]
- Palacky University [PrF_2012_028]
- European Community [CZ.1.05/2.1.00/03.0058, CZ.1.05/1.1.00/02.0068]
- 'Capacities' specific program [286154]
- European Social Fund [CZ.1.07/2.3.00/20.0017]
- PhD. Talent program by Brno City Municipality
Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz.
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