期刊
NUCLEIC ACIDS RESEARCH
卷 40, 期 17, 页码 8662-8673出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks616
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资金
- National Council for Scientific and Technological Development (CNPq, Brazil)
- German Academic Exchange Service (DAAD)
- state of Baden-Wurttemberg (HBIGS)
- Mannheim University of Applied Sciences
Streptomyces davawensis is the only organism known to synthesize the antibiotic roseoflavin, a riboflavin (vitamin B-2) analog. Roseoflavin is converted to roseoflavin mononucleotide (RoFMN) and roseoflavin adenine dinucleotide in the cytoplasm of target cells. (Ribo-)Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for the biosynthesis and transport of riboflavin. Streptomyces davawensis is roseoflavin resistant, and the closely related bacterium Streptomyces coelicolor is roseoflavin sensitive. The two bacteria served as models to investigate roseoflavin resistance of S. davawensis and to analyze the mode of action of roseoflavin in S. coelicolor. Our experiments demonstrate that the ribB FMN riboswitch of S. davawensis (in contrast to the corresponding riboswitch of S. coelicolor) is able to discriminate between the two very similar flavins FMN and RoFMN and shows opposite responses to the latter ligands.
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