期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 4, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks1323
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资金
- SystemsX.ch grant DynamiX-RTD
Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.
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