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Martin Schlee et al.
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M Sioud
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Maureen K. Purcell et al.
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PJF Leuschner et al.
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AD Judge et al.
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B Magnadóttir
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RI Gregory et al.
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C Matranga et al.
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TA Rand et al.
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JT Marques et al.
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PE Phelan et al.
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AD Judge et al.
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V Hornung et al.
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J Elmen et al.
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NJ Caplen et al.
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