期刊
NUCLEIC ACIDS RESEARCH
卷 40, 期 W1, 页码 W604-W608出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks562
关键词
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资金
- Office of Science, Office of Biological and Environmental Research, of the US Department of Energy (DOE) [DE-AC02-05CH11231]
- DOE Systems Biology Knowledgebase [DE-SC0004999]
- Sanford-Burnham Medical Research Institute
- Lawrence Berkeley National Laboratory, as part of Genomic Science Program
- DOE [DE-AC02-05CH11231]
Web services application programming interface (API) was developed to provide a programmatic access to the regulatory interactions accumulated in the RegPrecise database (http://regprecise.lbl.gov), a core resource on transcriptional regulation for the microbial domain of the Department of Energy (DOE) Systems Biology Knowledgebase. RegPrecise captures and visualize regulogs, sets of genes controlled by orthologous regulators in several closely related bacterial genomes, that were reconstructed by comparative genomics. The current release of RegPrecise 2.0 includes > 1400 regulogs controlled either by protein transcription factors or by conserved ribonucleic acid regulatory motifs in > 250 genomes from 24 taxonomic groups of bacteria. The reference regulons accumulated in RegPrecise can serve as a basis for automatic annotation of regulatory interactions in newly sequenced genomes. The developed API provides an efficient access to the RegPrecise data by a comprehensive set of 14 web service resources. The RegPrecise web services API is freely accessible at http://regprecise.lbl.gov/RegPrecise/services.jsp with no login requirements.
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