期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 4, 页码 2683-2688出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks1304
关键词
-
资金
- Singapore Biomedical Research Council
- Singapore Ministry of Education
- Nanyang Technological University
Interlock is a structural element in DNA G-quadruplexes that can be compared with the commonly used complementary binding of 'sticky ends' in DNA duplexes. G-quadruplex interlocking can be a basis for the assembly of higher-order structures. In this study, we formulated a rule to engineer (3 + 1) interlocked dimeric G-quadruplexes and established the folding topology of the designed DNA sequences by nuclear magnetic resonance spectroscopy. These interlocked G-quadruplexes are very stable and can serve as compact robust scaffolds for various applications. Different structural elements can be engineered in these robust scaffolds. We demonstrated the anti-HIV inhibition activity of the newly designed DNA sequences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据