期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 -, 页码 W13-W17出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr245
关键词
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资金
- Plan Nacional [BFU2008-00419]
- European Commission
- LEISHDRUG [223414]
- Quantomics project [KBBE-2A-222664]
- CUR of DIUE of GENCAT
- Spanish ministry of education [TIN2008-05913]
- Consolider project [CSD 2007-00050]
- Super-computacion y e-Ciencia (SYEC)
This article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly related sequences using homology extension. The new server benefits from recent improvements of the T-Coffee algorithm and can align up to 150 sequences as long as 10 000 residues and is available from both http://tcoffee.crg.cat.
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