期刊
NUCLEIC ACIDS RESEARCH
卷 40, 期 5, 页码 1891-1903出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr681
关键词
-
资金
- European Research Council under the European Community [249835]
This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base-base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.
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