期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 9, 页码 3864-3878出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1348
关键词
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资金
- National High Technology Research and Development of China [2008AA02Z306]
- Chinese Academy of Sciences [KSCX2-EW-R-01]
- National Program on Key Basic Research Project [2010CB530004]
- National Natural Science Foundation of China [31071137, 30771888, 30972574]
Although accumulating evidence has provided insight into the various functions of long-non-coding RNAs (lncRNAs), the exact functions of the majority of such transcripts are still unknown. Here, we report the first computational annotation of lncRNA functions based on public microarray expression profiles. A coding-non-coding gene co-expression (CNC) network was constructed from re-annotated Affymetrix Mouse Genome Array data. Probable functions for altogether 340 lncRNAs were predicted based on topological or other network characteristics, such as module sharing, association with network hubs and combinations of co-expression and genomic adjacency. The functions annotated to the lncRNAs mainly involve organ or tissue development (e.g. neuron, eye and muscle development), cellular transport (e.g. neuronal transport and sodium ion, acid or lipid transport) or metabolic processes (e.g. involving macromolecules, phosphocreatine and tyrosine).
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